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Cell Signalling - John Hancock
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Signalling
John
Hancock
Cell
文档概述
Cell Signalling
书籍目录
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Dedication
Title Page
Copyright Page
■ PREFACE
■ LIST OF ABBREVIATIONS
Part 1 - An overview of signalling
Chapter 1 - Aspects of cellular signalling
1.2 The main principles of cell signalling
1.3 What makes a good signal?
1.4 Different ways in which cells signal to each other
1.4 Different ways in which cells signal to each other
Electrical and synaptic
Endocrine
Paracrine
Autocrine
1.5 Amplification and physical architectures
1.6 Coordination of signalling
1.7 Domains and modules
1.7 Domains and modules
1.8 Oncogenes
1.8 Oncogenes
Chapter 2 - Pathways are the key to signalling
2.2 Simplified examples of signalling pathways
2.2 Simplified examples of signalling pathways
Chapter 3 - A look at some of the history and techniques of cell signalling
3.2 A brief look at some techniques
3.2 A brief look at some techniques
Biochemistry and labelling studies
The use of probes
Pharmacological tools
Structure and protein interactions
Molecular genetic techniques
Microarrays and proteomics
Computer networks
Part 2 - Components that comprise signalling pathways
Chapter 4 - Extracellular signals: hormones, cytokines and growth factors
4.2 Hormones
4.2 Hormones
Small water soluble molecules
Peptide hormones
Lipophilic molecules that are detected by cell surface receptors
4.3 Plant hormones
4.3 Plant hormones
Auxin
Cytokinins
Gibberellins
Abscisic acid
Ethylene
4.4 Cytokines
4.4 Cytokines
Interleukins
Interferons
Tumour necrosis factors
4.5 Growth factors
4.5 Growth factors
Platelet-derived growth factors
Epidermal growth factor
4.6 Neurotransmitters
4.7 ATP as an extracellular signal
4.8 Pheromones
4.8 Pheromones
Chapter 5 - Detection of extracellular signals: the role of receptors
5.2 Types of receptors
5.2 Types of receptors
G protein-coupled receptors
Ion channel linked receptors
Receptors containing intrinsic enzymatic activity
Receptors linked to separate tyrosine kinases
5.3 Ligand binding to their receptors
5.4 Receptor sensitivity and receptor density
5.4 Receptor sensitivity and receptor density
Chapter 6 - Protein phosphorylation, kinases and phosphatases
6.2 Serine/threonine kinases
6.2 Serine/threonine kinases
cAMP-dependent protein kinase
cGMP-dependent protein kinase.
Protein kinase C
Ca2+-calmodulin-dependent protein kinases
G protein-coupled receptor kinases
Protein kinase B
AMP-activated protein kinase
Haem regulated protein kinase
6.3 Tyrosine kinases
6.3 Tyrosine kinases
Receptor tyrosine kinases
6.4 Mitogen-activated protein kinases
6.5 Histidine phosphorylation
6.6 Phosphatases
6.6 Phosphatases
Serine/threonine phosphatases
6.7 Other covalent modifications
6.8 Ubiquitin-proteasome system
6.8 Ubiquitin-proteasome system
Chapter 7 - Cyclic nucleotides, cyclases and G proteins
7.2 cAMP
7.3 Adenylyl cyclase
7.4 Adenylyl cyclase control and the role of G proteins
7.4 Adenylyl cyclase control and the role of G proteins
The heterotrimeric G protein family
7.5 Other roles of the heterotrimeric G proteins
7.6 Guanylyl cyclase
7.6 Guanylyl cyclase
Soluble guanylyl cyclase
7.7 Phosphodiesterases
7.8 Compartmentalization of nucleotide signalling
7.9 The GTPase superfamily: functions of monomeric G proteins
7.9 The GTPase superfamily: functions of monomeric G proteins
Other Ras related proteins
Chapter 8 - Inositol phosphate metabolism and roles of membrane lipids
8.2 Events at the membrane
8.3 The breakdown of the inositol phosphate lipids
8.3 The breakdown of the inositol phosphate lipids
8.4 Inositol 1,4,5 trisphosphate and its fate
8.5 The role of diacylglycerol
8.6 Inositol phosphate metabolism at the nucleus
8.7 Other lipids involved in signalling
8.7 Other lipids involved in signalling
Phosphatidylcholine and arachidonic acid metabolism
8.8 Related lipid derived signalling molecules
8.8 Related lipid derived signalling molecules
Chapter 9 - Intracellular calcium: its control and role as an intracellular signal
9.2 Calmodulin
9.3 The plasma membrane and its role in calcium concentration maintenance
9.4 Intracellular stores
9.4 Intracellular stores
Endoplasmic reticulum stores
9.5 Gradients, waves and oscillations
9.6 Sphingosine-1-phosphate
9.7 Cyclic ADP-ribose
9.8 Nicotinate adenine-dinucleotide phosphate
9.9 Fluorescence detection and confocal microscopy
9.9 Fluorescence detection and confocal microscopy
Chapter 10 - Reactive oxygen species, reactive nitrogen species and redox signalling
10.2 Nitric oxide
10.2 Nitric oxide
10.3 Reactive oxygen species: superoxide and hydrogen peroxide
10.3 Reactive oxygen species: superoxide and hydrogen peroxide
Evidence for superoxide and hydrogen peroxide acting as a signal
The NADPH oxidase complex
10.4 Redox signalling and molecular mechanisms of hydrogen peroxide signalling
10.5 Measuring ROS and RNS
10.6 Carbon monoxide and other compounds
10.6 Carbon monoxide and other compounds
Part 3 - Selected examples of signalling pathways and events
Chapter 11 - Insulin and the signal transduction cascades it invokes
11.1 The insulin signalling system
Literature link
Chapter 12 - Perception of the environment
12.2 Photodetection in the eye
12.3 Other environment perception systems
12.3 Other environment perception systems
Chapter 13 - Signalling in development and for the regulation of gene expression
13.2 Transcription factors
13.2 Transcription factors
Activation by phosphorylation
Activation by oxidation
13.3 Transforming growth factor ß
13.4 Notch receptor signalling
13.5 Hedgehog signalling
13.6 Wnt signalling
13.7 Toll-like receptor signalling
13.7 Toll-like receptor signalling
Chapter 14 - Life, death and apoptosis
14.2 An overview of apoptosis
14.3 Caspases
14.4 The intrinsic pathway
14.5 The extrinsic pathway
14.5 The extrinsic pathway
Death receptors
Signalling from death receptors
Part 4 - Final thoughts
Chapter 15 - Cell signalling: importance, complexity and the future
15.2 Specificity, subtlety and crosstalk
15.3 Longer term effects
15.4 The future
15.4 The future
■ INDEX
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
R
S
T
U
V
W
X
Y
Z
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