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Cell Signalling - John Hancock
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Dedication

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2022-02-24 00:43:47
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  • Dedication
  • Title Page
  • Copyright Page
  • ■ PREFACE
  • ■ LIST OF ABBREVIATIONS
  • Part 1 - An overview of signalling
  • Chapter 1 - Aspects of cellular signalling
  • 1.2 The main principles of cell signalling
  • 1.3 What makes a good signal?
  • 1.4 Different ways in which cells signal to each other
  • 1.4 Different ways in which cells signal to each other
  • Electrical and synaptic
  • Endocrine
  • Paracrine
  • Autocrine
  • 1.5 Amplification and physical architectures
  • 1.6 Coordination of signalling
  • 1.7 Domains and modules
  • 1.7 Domains and modules
  • 1.8 Oncogenes
  • 1.8 Oncogenes
  • Chapter 2 - Pathways are the key to signalling
  • 2.2 Simplified examples of signalling pathways
  • 2.2 Simplified examples of signalling pathways
  • Chapter 3 - A look at some of the history and techniques of cell signalling
  • 3.2 A brief look at some techniques
  • 3.2 A brief look at some techniques
  • Biochemistry and labelling studies
  • The use of probes
  • Pharmacological tools
  • Structure and protein interactions
  • Molecular genetic techniques
  • Microarrays and proteomics
  • Computer networks
  • Part 2 - Components that comprise signalling pathways
  • Chapter 4 - Extracellular signals: hormones, cytokines and growth factors
  • 4.2 Hormones
  • 4.2 Hormones
  • Small water soluble molecules
  • Peptide hormones
  • Lipophilic molecules that are detected by cell surface receptors
  • 4.3 Plant hormones
  • 4.3 Plant hormones
  • Auxin
  • Cytokinins
  • Gibberellins
  • Abscisic acid
  • Ethylene
  • 4.4 Cytokines
  • 4.4 Cytokines
  • Interleukins
  • Interferons
  • Tumour necrosis factors
  • 4.5 Growth factors
  • 4.5 Growth factors
  • Platelet-derived growth factors
  • Epidermal growth factor
  • 4.6 Neurotransmitters
  • 4.7 ATP as an extracellular signal
  • 4.8 Pheromones
  • 4.8 Pheromones
  • Chapter 5 - Detection of extracellular signals: the role of receptors
  • 5.2 Types of receptors
  • 5.2 Types of receptors
  • G protein-coupled receptors
  • Ion channel linked receptors
  • Receptors containing intrinsic enzymatic activity
  • Receptors linked to separate tyrosine kinases
  • 5.3 Ligand binding to their receptors
  • 5.4 Receptor sensitivity and receptor density
  • 5.4 Receptor sensitivity and receptor density
  • Chapter 6 - Protein phosphorylation, kinases and phosphatases
  • 6.2 Serine/threonine kinases
  • 6.2 Serine/threonine kinases
  • cAMP-dependent protein kinase
  • cGMP-dependent protein kinase.
  • Protein kinase C
  • Ca2+-calmodulin-dependent protein kinases
  • G protein-coupled receptor kinases
  • Protein kinase B
  • AMP-activated protein kinase
  • Haem regulated protein kinase
  • 6.3 Tyrosine kinases
  • 6.3 Tyrosine kinases
  • Receptor tyrosine kinases
  • 6.4 Mitogen-activated protein kinases
  • 6.5 Histidine phosphorylation
  • 6.6 Phosphatases
  • 6.6 Phosphatases
  • Serine/threonine phosphatases
  • 6.7 Other covalent modifications
  • 6.8 Ubiquitin-proteasome system
  • 6.8 Ubiquitin-proteasome system
  • Chapter 7 - Cyclic nucleotides, cyclases and G proteins
  • 7.2 cAMP
  • 7.3 Adenylyl cyclase
  • 7.4 Adenylyl cyclase control and the role of G proteins
  • 7.4 Adenylyl cyclase control and the role of G proteins
  • The heterotrimeric G protein family
  • 7.5 Other roles of the heterotrimeric G proteins
  • 7.6 Guanylyl cyclase
  • 7.6 Guanylyl cyclase
  • Soluble guanylyl cyclase
  • 7.7 Phosphodiesterases
  • 7.8 Compartmentalization of nucleotide signalling
  • 7.9 The GTPase superfamily: functions of monomeric G proteins
  • 7.9 The GTPase superfamily: functions of monomeric G proteins
  • Other Ras related proteins
  • Chapter 8 - Inositol phosphate metabolism and roles of membrane lipids
  • 8.2 Events at the membrane
  • 8.3 The breakdown of the inositol phosphate lipids
  • 8.3 The breakdown of the inositol phosphate lipids
  • 8.4 Inositol 1,4,5 trisphosphate and its fate
  • 8.5 The role of diacylglycerol
  • 8.6 Inositol phosphate metabolism at the nucleus
  • 8.7 Other lipids involved in signalling
  • 8.7 Other lipids involved in signalling
  • Phosphatidylcholine and arachidonic acid metabolism
  • 8.8 Related lipid derived signalling molecules
  • 8.8 Related lipid derived signalling molecules
  • Chapter 9 - Intracellular calcium: its control and role as an intracellular signal
  • 9.2 Calmodulin
  • 9.3 The plasma membrane and its role in calcium concentration maintenance
  • 9.4 Intracellular stores
  • 9.4 Intracellular stores
  • Endoplasmic reticulum stores
  • 9.5 Gradients, waves and oscillations
  • 9.6 Sphingosine-1-phosphate
  • 9.7 Cyclic ADP-ribose
  • 9.8 Nicotinate adenine-dinucleotide phosphate
  • 9.9 Fluorescence detection and confocal microscopy
  • 9.9 Fluorescence detection and confocal microscopy
  • Chapter 10 - Reactive oxygen species, reactive nitrogen species and redox signalling
  • 10.2 Nitric oxide
  • 10.2 Nitric oxide
  • 10.3 Reactive oxygen species: superoxide and hydrogen peroxide
  • 10.3 Reactive oxygen species: superoxide and hydrogen peroxide
  • Evidence for superoxide and hydrogen peroxide acting as a signal
  • The NADPH oxidase complex
  • 10.4 Redox signalling and molecular mechanisms of hydrogen peroxide signalling
  • 10.5 Measuring ROS and RNS
  • 10.6 Carbon monoxide and other compounds
  • 10.6 Carbon monoxide and other compounds
  • Part 3 - Selected examples of signalling pathways and events
  • Chapter 11 - Insulin and the signal transduction cascades it invokes
  • 11.1 The insulin signalling system
  • Literature link
  • Chapter 12 - Perception of the environment
  • 12.2 Photodetection in the eye
  • 12.3 Other environment perception systems
  • 12.3 Other environment perception systems
  • Chapter 13 - Signalling in development and for the regulation of gene expression
  • 13.2 Transcription factors
  • 13.2 Transcription factors
  • Activation by phosphorylation
  • Activation by oxidation
  • 13.3 Transforming growth factor ß
  • 13.4 Notch receptor signalling
  • 13.5 Hedgehog signalling
  • 13.6 Wnt signalling
  • 13.7 Toll-like receptor signalling
  • 13.7 Toll-like receptor signalling
  • Chapter 14 - Life, death and apoptosis
  • 14.2 An overview of apoptosis
  • 14.3 Caspases
  • 14.4 The intrinsic pathway
  • 14.5 The extrinsic pathway
  • 14.5 The extrinsic pathway
  • Death receptors
  • Signalling from death receptors
  • Part 4 - Final thoughts
  • Chapter 15 - Cell signalling: importance, complexity and the future
  • 15.2 Specificity, subtlety and crosstalk
  • 15.3 Longer term effects
  • 15.4 The future
  • 15.4 The future
  • ■ INDEX
  • A
  • B
  • C
  • D
  • E
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  • G
  • H
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